Another randomized, placebo-controlled, double-blind trial with 1-year follow-up in dialysis patients with a 25(OH)D concentration < 50 nmol/L showed that compared to placebo, 50.000 IU/week oral cholecalciferol had no effect on muscle strength, blood pressure, bone parameters, levels of calcium, phosphorus, PTH, or cardiac ischemia [88]. Here, PTH is linked to myocardial ischemia.