Combined meta-analyses and single-cell atlases highlight inflammatory and proteostatic remodeling, as well as metabolic rewiring (including TNFα/NF-κB activation, UPR/proteostasis engagement, and changes in oxidative metabolism) in AMD regions, paralleling the pathway enrichments observed in Prom1-KO mRPE cells. This evidence concerns the gene NFKB1 and age-related macular degeneration.