PPARA and metabolic dysfunction-associated steatohepatitis: Recently, it was found that isoLCA administration to HFD-induced C57BL/6J mice NASH model prevented the progression of NAFLD to NASH by regulating the expression of genes related to TH17 cell differentiation/IL-17/PPAR signaling pathway to inhibit TH17 cell differentiation and promote Treg cell proliferation [71].