The transcription factor hypoxia-inducible factor-1α (HIF-1α) orchestrates angiogenesis, metabolic rewiring, extracellular matrix (ECM) remodeling, and immune evasion, and high HIF-1α expression in gastric cancer correlates with greater microvessel density, nodal metastasis, and advanced stage [127,128,129]. This evidence concerns the gene HIF1A and gastric cancer.