AQP4 and myalgic encephalomeyelitis/chronic fatigue syndrome: Additional glymphatic modulation drugs that may also improve astrocyte and AQP4 function in ME/CFS include atipamezole, escitalopram [65], and systemic dexmedetomidine (promotes slow-wave activity, with a ∼32% increase in tracer influx and a ∼6-fold increase in hippocampal clearance) [198].