NPY and epilepsy: The main source of NPY in the central and peripheral nervous systems is the arcuate nucleus [5,8,13,14], although NPY has also been shown to be highly expressed in the adrenal glands, white adipose tissue, and bone, among other tissues, indicating the potential involvement of this neuropeptide in a wide range of physiological responses, including adipogenesis, regulation of bone mass and energy metabolism, locomotion, anxiety, learning and memory, epilepsy, circadian rhythm, and cardiovascular function [15,16,17,18,19,20,21,22].