In mice with acute and chronic DSS-induced colitis, after MP exposure, they demonstrated higher colon mRNA expression of proinflammatory cytokine genes (Tnfa, Il1b, Il6, Il17a, Il22, and Tgfb), lower expression of anti-inflammatory cytokine Il10, and increased colonic level of proinflammatory cytokines TNF-α, IL-1β, and IL-6 [26,27,28,86]. The gene discussed is TNF; the disease is colitis.