CASP3 and neoplasm: However, for an accurate assessment of the differentiation progression and malignancy of the tumor, an immunohistochemical study of a number of markers should be carried out: proliferation marker Ki-67, a component of the Wnt signaling pathway involved in the regulation of proliferation and migration—β-catenin, apoptosis inductor caspase-3, tumor-suppressor p53, and proteins of intermediate filaments of epithelial cells cytokeratins [87].