In the murine cortical neurons, IFN-β expression was higher at 4 h, followed by a downregulation pattern at the tested timepoints of 16 h and 24 h, and then showed a rapid increase at 48 h and a reduction at 72 h and 120 h post ZIKV infection (Figure 3F). The gene discussed is IFNB1; the disease is Zika virus infectious disease.