PSEN1 and amyotrophic lateral sclerosis: Unlike DAMs, which were initially defined in the context of amyloid pathology, MGnD arises not only in AD models such as APP/PS1 mice, but also in experimental autoimmune encephalomyelitis (EAE) and amyotrophic lateral sclerosis (ALS; SOD1 model), indicating that it constitutes a shared and pathology-independent response of microglia to neurodegenerative stress [76].