When tumors reached ~5 mm2 in size (6 days post tumor inoculation), mice were treated with either control antibody (anti-IgG isotype in PBS (i.p.), IL-15 complexes (IL-15Rα-Fc labeled with Cy5) (i.t.), and anti-PD-1 mAb (labeled with Cy3) (i.p.)or a combination of anti-PD-1 mAb (i.p.)and IL-15 complexes (i.t.)or PBS/IgG isotype (i.t.). The gene discussed is IL15RA; the disease is neoplasm.