Down-regulation of hypoxia-associated genes along with itga6 in response to combined treatment with IL-15 complexes and anti-PD-1 mAb therapy demonstrates how immune control of breast cancer by killing tumor cells and disrupting tumor metabolism can, in turn, attenuate tumor cell adhesion, stemness, metastasis, and even drug resistance via the downregulation of itga6 in tumor cells [51,52]. The gene discussed is IL15; the disease is breast cancer.