Likewise, DEL-22379 displays activity in other ERK2 dimerization-related functions, such as in memory reconsolidation and synaptic plasticity, inhibiting hippocampal ERK2 dimerization in EGF-stimulated in vivo results [26]; or in anaplastic thyroid cancer induced by BRAF mutation [13]. Here, MAPK1 is linked to thyroid gland undifferentiated (anaplastic) carcinoma.