Nevertheless, S814 in mouse TRPC6 (S815 in human TRPC6) occurred as constitutively phosphorylated in high throughput screenings, for example, in spleen [38,39,40], lung [38,40], thymus [40], blood [40], and colorectal cancer samples [41] and in non-small cell lung cancer tumors [42] in patients, suggesting that S814 might be important for the regulation of TRPC6 channel activity. Here, TRPC6 is linked to colorectal cancer.