In renal proximal tubule epithelial cells, which endogenously express TRPC6 (and possibly TRPC3), PKC inhibition slowed OptoDArG-induced kinetics and increased current density amplitudes, suggesting physiological relevance in renal pathophysiology, including ischemia–reperfusion injury [66] and renal cancer [67]. This evidence concerns the gene PRRT2 and renal carcinoma.