In the cardiovascular system, TRPC6 contributes to cardiac hypertrophy [6,7], vasoconstriction [8,9], and pulmonary arterial hypertension [10,11], and in the central nervous system, TRPC6 has been associated with neurodegenerative disorders, including Alzheimer’s disease [12]. The gene discussed is TRPC6; the disease is pulmonary arterial hypertension.