In a recent work, circNF1, a circRNA generated from the circularization of the neurofibromatosis type 1 (NF1) gene, was found to act as dual regulator on PD-L1 level from transcriptional and post-translational point of view, boosting the levels of this protein in esophageal squamous cell carcinoma (ESCC). Here, NF1 is linked to esophageal squamous cell carcinoma.