The aim was to evaluate the association between single-nucleotide polymorphisms (SNPs) in genes involved in inflammation and bone metabolism (BMP-4, BRINP3, CD14, FGF-3, FGF-10, GBP-1, IL-1α, IL-1β, IL-10, LTF, OPG, and RANKL) and peri-implantitis. This evidence concerns the gene TNFSF11 and Peri-Implantitis.