Compared with the SIN group, the SIN-NLCs group exhibited lower concentrations of interleukin 1β (IL-1β), Serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), indicating that this group significantly suppressed the secretion of proinflammatory cytokines and alleviated the severity of RA, as shown in Figure 7A–C. This evidence concerns the gene IL6 and rheumatoid arthritis.