STING plays a crucial role in regulating the delicate balance of the immune response, and overactivation of STING has been associated with several autoinflammatory and autoimmune diseases, including STING-associated infantile vascular disease (SAVI) and inflammatory bowel disease (IBD) and systemic lupus erythematosus [40,41,42]. This evidence concerns the gene STING1 and STING-associated vasculopathy with onset in infancy.