These immune-related signatures in cluster 1 may have important clinical implications—interleukin-6 is a well-established pro-inflammatory cytokine associated with aggressive tumor phenotypes and poor prognosis in hepatocellular carcinoma (HCC), suggesting that tumor cell cluster 1 with higher infiltration or activity may carry an increased risk of recurrence or distant metastasis [29,30]. The gene discussed is IL6; the disease is neoplasm.