Macrophages also migrate to the tumor site, where tumor cells are responsible for a switch in macrophage phenotype, favoring a pro-invasive and immunosuppressive M2 state via the release of immunosuppressive factors, such as CSF-1, CCL2, IL-4, IL-6, IL-10, and TGF-β [58]. The gene discussed is TGFB1; the disease is neoplasm.