In this study, cathepsin S levels were higher in T2D compared to controls at baseline in accordance with the findings of others [22] and there was a significant decrease in the T2D group compared to the control group from baseline to 24 h, suggesting that the effects of hypoglycaemia appear to persist, with the result that, hypothetically, there may be some impairment in osteoclastic bone resorption. This evidence concerns the gene CTSS and type 2 diabetes mellitus.