It has been reported that, in those with both type 1 diabetes and insulin-treated subjects with T2D, recurrent hypoglycaemia has been associated with an increased fracture rate, primarily due to falls [17], suggesting that an additional mechanism may be long-term skeletal effects due to chronic hypoglycaemia compromising bone that may then fracture more easily with a fall [18]. Here, INS is linked to type 2 diabetes mellitus.