RAPGEF3 and neoplasm: The elevated expression of leukocyte transendothelial migration-related genes (CTNND1, PXN, PIK3R3, PTK2, GNAI2, CDH5, CLDN5, PECAM1, CTNNB1, RAPGEF3, ICAM2) may suggest the recruitment of monocytes, granulocytes, and lymphocytes to the tumor, considering previous data [35].