ADGRE5 and neoplasm: This cluster also has immunosuppressive (IL10RA, CD209, MAF, GRN), myeloid and immune checkpoint-related (SIGLEC1, SIRPA, CSF1R, HAVCR2; [29,30]; Figure 3E), stem cell (CD44), cytoskeletal regulator (SDC), and anti-tumor effector (CD14, CD40, TLR2) markers, as well as various receptor genes (C3AR1, ADGRE5, PECAM1, ITGB2).