However, others have shown a contrasting effect, where survivin expression is reduced in certain glioma patient-derived cells, such as the diffuse intrinsic pontine glioma (DIPG) patient-derived cell (PDC) line SF7761, compared to other DIPG PDCs that typically exhibit survivin upregulation after irradiation [56]. Here, BIRC5 is linked to diffuse intrinsic pontine glioma.