The exogenous H2S donor, NaHS, amplifies the apoptotic process in melanoma A375 and SK-MEL-282 cells, demonstrating the antitumor effect of H2S treatment at high concentrations (via suppression of the PI3K/AKT/mTOR, NF-KB, AKT, ERK1/2, MAPK/ERK, PI3K/Akt pathways, FLIP, XIAP, Bcl-2, PHLDA genes) [8,11,49,50]. The gene discussed is AKT1; the disease is melanoma.