Other studies demonstrated that melanoma cell lines A-375 and SK-MEL-28, treated with Sodium Hydrosulfide (NaSH), showed: (1) a significant reduction of p-PI3K, p-Akt, and mTOR proteins; (2) blocked proliferation, migration, and cell cycle progression; and (3) induction of apoptosis and autophagy. This evidence concerns the gene AKT1 and melanoma.