Among the 353 candidate genes, RBM33 has been identified as being significantly associated with obesity in Northern Han Chinese by targeted resequencing technology [21], and as an RNA-binding protein, RBM333 regulates m6A methylation modification [22], an essential post-transcriptional regulator implicated in skeletal myogenesis [23]. Here, RBM33 is linked to obesity due to melanocortin 4 receptor deficiency.