Moreover, this observation was supported with Q-PCR data on the expression of known osteoporosis and cellular matrix degradation marker genes: Rankl (associated with bone resorption) [51], Trap (marker of osteoclast activity), Mmp9 (cellular matrix degrader) [52,53], Tsc2 (hypoxia-induced negative regulator of proliferation) [54], and Bglap (osteogenic marker) [55,56]. Here, TSC2 is linked to osteoporosis.