ADAM17 and chronic kidney disease: The 95 kDa transmembrane CX3CL1 (mCX3CL1) is cleaved into soluble CX3CL1 (sCX3CL1), containing CKD, by metalloproteases ADAM17/TACE [34] and ADAM10 [35] (65–70 kDa sCX3CL1) and cathepsin S [36] produced by microglia (40 kDa sCX3CL1) [37].