Functional analysis using 2D and 3D FLNB and FLNB-PTCH1 knockdown models demonstrated a ‘morphoeic-like’ phenotype with less compact colonies, more migratory and invasive phenotype, and attraction of fibroblasts, which is a specific hallmark required for the diagnosis of morphoeic BCC in vivo. The gene discussed is PTCH1; the disease is skin basal cell carcinoma.