TGFB1 and skin basal cell carcinoma: Genomic analysis of 293 BCC revealed seven significantly mutated genes (PTCH1, TP53, SMO, MYCN, PTPN14, RPL22 and PPIAL4G) and dysregulated pathways such as TGF-β plus TP53, but there was a bias towards the nodular subtype, with only eight mBCC undergoing whole-exome sequencing (WES) and not from the eyelid region [23,24].