PDGFB is overexpressed in morphoeic tumours compared to nodular tumours by four folds (p = 0.01), and the PDGFB-GLI2 axis is known to modulate cancer stem cell properties; thus, this axis may be more important in determining the GLI2 dominance seen in morphoeic BCC, although this requires future investigation to support this hypothesis [47]. This evidence concerns the gene PDGFB and skin basal cell carcinoma.