These quantitative differences between MCD and MN are compatible with their known pathophysiological backgrounds: MN is an autoimmune disease associated with autoantibodies against podocyte antigens (PLA2R, THSD7A), whereas MCD is characterized by a predominant involvement of T lymphocytes and cytokines, mainly IL-13, leading to functional podocyte dysfunction without the formation of immune deposits [1,11,58,59,60,61,62]. Here, PLA2R1 is linked to autoimmune disease.