Chromosomal translocations are pivotal events in T-ALL, frequently resulting in the juxtaposition of T-cell receptor (TCR) promoters on chromosomes 7 (TCRB, TCRG) and 14 (TCRA, TCRD) with transcription factors such as TAL1, LYL1, and HOX11, thereby inducing aberrant transcriptional programs that drive leukemogenesis [17]. The gene discussed is TAL1; the disease is acute lymphoblastic leukemia.