ETV6-RUNXI, which results from the t(12;21) translocation, is observed in one-quarter of children with ALL and is associated with a favorable prognosis, whereas TCF3-HLF—resulting from the translocation (t17;19)—is rare (<1% of children with BCP-ALL) and prognostically extremely unfavorable [12]. Here, TCF3 is linked to acute lymphoblastic leukemia.