The most recurrent side effects are opportunistic infections, mucositis, bone toxicities, central or/and peripheral neuropathy, endocrinopathies, hyperlipidemia, sinusoidal obstruction syndrome (SOS) and hepatotoxicity, thromboembolism (TE), HD-MTX-induced nephrotoxicity, asparaginase-associated hypersensitivity, allergy, and pancreatitis [37]. This evidence concerns the gene ASPG and hyperlipidemia.