Genetically, ETP-ALL is heterogeneous, harboring mutations in pathways related to hematopoietic and lymphoid development (RUNX1, IKZF1, ETV6, GATA3, and EP300), Ras and cytokine receptor signaling (NRAS, IL7R, KRAS, JAK1, JAK3, NF1, and PTPN11), and epigenetic regulators (EZH2, SUZ12, EED, and SETD2) [13]. The gene discussed is IL7R; the disease is acute lymphoblastic leukemia.