Other relevant gene alterations that should be assessed in children with B-precursor ALL are TCF3-HLF (or E2A-HLF), TCF3-PBX1 (or E2A-PBX1), and ETV6-RUNX1 (or TEL-AML1), and, most importantly, hypodiplody should be ascertained in all BCP-ALL patients. This evidence concerns the gene TCF3 and acute lymphoblastic leukemia.