TBXT and Alzheimer disease: Alzheimer’s disease (AD) is particularly associated with progressive accumulation of extracellular amyloid plaques of Aβ peptide (40 (Aβ40) to 42 (Aβ42) amino acids long) in the human brain [1,2,3,4,5,6,7,8,9,10], characterized by extracellular deposition of amyloid β (Aβ) peptides, predominantly Aβ40 and Aβ42, and intracellular neurofibrillary tangles composed of hyperphosphorylated τ-protein [11,12,13,14,15,16] that can cross the blood–brain barrier and reach the blood plasma [5,17].