Initial genetic studies revealed that the most common, late-onset FECD is associated with rare mutations in genes such as solute carrier family 4 sodium borate transporter member 11 (SLC4A11), transcription factor 8 gene (TCFG8), transcription factor 4 gene (TCF4), lipoxygenase homology domains 1 (LOXHD1) and ATP/GTP binding protein like 1 (AGBL1) [1,12,13,14,15]. The gene discussed is TCF4; the disease is Fuchs endothelial corneal dystrophy.