CTGF demonstrates a suboptimal predictive power, with an AUC of 0.694 (95% CI = 0.604 to 0.785) for all-cause mortality, 0.705 (95% CI = 0.597 to 0.812) for CV mortality, and 0.737 (95% CI = 0.456 to 1.000) for SCD. The gene discussed is CCN2; the disease is Schnyder corneal dystrophy.