It has been suggested that LBP plays a role in binding lipopolysaccharide and facilitating its transfer to toll-like receptor 4 (TLR4) complex [19,20], which initiates an extensive cell signaling pathway leading to an inflammatory response and cytokine expression and secretion, and is considered a critical factor in NAFLD development [20,21]. This evidence concerns the gene TLR4 and metabolic dysfunction-associated steatotic liver disease.