In a meta-analysis of the discordance between ER, PgR, and HER-2 status of the primary tumour, the pooled proportions of tumours changing from positive expression of these biomarkers and the reverse were 24% and 14%, respectively, for the expression of ER, 46% and 15% for PgR, and 13% and 5% for HER-2 [74]. This evidence concerns the gene ERBB2 and neoplasm.