Moreover, the finding of a high PTX3 plasma concentration in one patient in which the tissue expression of PTX3 was virtually absent suggests that PTX3 could also be even synthesized outside the tumor site, such as the liver, potentially upon the stimulatory effects of other systemic proinflammatory cytokines, such as IL-6, also reported to be increased in ATC [25]. This evidence concerns the gene IL6 and neoplasm.