FBXW7 and colorectal carcinoma: DYRK2 (Dualspecificity tyrosine-phosphorylation-regulated kinase 2) is a Ser/Thr kinase that affects FBXW7 stability in response to DNA damage and sensitivity to chemotherapeutic drug such as Doxorubicin or Paclitaxel [60].The microRNA (miR)-223/FBXW7 pathway has also been implicated in the mechanism of doxorubicin chemoresistance in CRC.