Notably, FBXW7 controls the expression of multiple oncoproteins, including Cyclin E1, transcriptional factors c-Myc and c-Jun, Notch receptor, SREBP (a coactivators of PARPγ) and transcriptional factor PGC-1α, thereby suppressing tumor development [5,6]. The gene discussed is FBXW7; the disease is neoplasm.