FBXW7 and metastatic malignant neoplasm in the lymph nodes: Reduced FBXW7 expression correlates with adverse clinicopathologic features (lymph-node metastasis, advanced TNM stage, perineural invasion) and poorer survival in some Chinese cohorts, and FBXW7 gene fusions have been reported alongside dMMR in poorly differentiated, hepatic-flexure-predominant tumors [78,98].