LCLAT1 (Lysocardiolipin acyltransferase 1), also known as ALCAT1, is a key enzyme in phospholipid remodeling that directly impacts mitochondrial function and oxidative stress, processes central to metabolic disease, which has recently been suggested to play a role in diabetes and obesity through epigenetic mechanisms [25,26]. This evidence concerns the gene LCLAT1 and obesity due to melanocortin 4 receptor deficiency.