Patients suffering from MS have B cells that display various abnormalities, such as excessive production of pro-inflammatory cytokines (TNF, lymphotoxin-α, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF)) [14,33] and a reduction in regulatory B cells (Breg) that produce IL-10 [34]. This evidence concerns the gene IL6 and myeloid sarcoma.