We also found that upon cultivating Mel Z cells on Matrigel, two big groups of developmental rDNA-contacting genes are associated with several other pathways—cAMF signaling, melanogenesis, longevity regulation, MAPK signaling, GnRH signaling, cholinergic synapse, and Cushing syndrome (Figures S2 and S4). This evidence concerns the gene GNRH1 and Cushing syndrome.