We also found that upon cultivating Mel Z cells on Matrigel, two big groups of developmental rDNA-contacting genes are associated with several other pathways—cAMF signaling, melanogenesis, longevity regulation, MAPK signaling, GnRH signaling, cholinergic synapse, and Cushing syndrome (Figures S2 and S4). The gene discussed is GNRH1; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.