Lactate generated by CRC cells promotes H3K18 lactylation in tumor-infiltrating myeloid cells (TIMs) and TAMs, inhibiting RARγ transcription in TAMs or enhancing methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit 3 (METTL3) transcription in TIMs. The gene discussed is METTL3; the disease is neoplasm.