Conversely, H3K18 lactylation also upregulates YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), which binds to m6A modification sites on period circadian regulator 1 (PER1) and TP53 RNA, promoting their degradation and exacerbating melanoma progression [20]. This evidence concerns the gene YTHDF2 and melanoma.