Additionally, in Treg cells co-cultured with glioblastoma cells, H3K18 lactylation enhances the transcription of genes such as C-C motif chemokine receptor 8 (CCR8) and ectonucleoside triphosphate diphosphohydrolase 1 (CD39), which diminishes the cytotoxic efficacy of CAR-T therapy against glioblastoma [191]. The gene discussed is CCR8; the disease is glioblastoma.