NR3C1 and Abdominal obesity: Similarly, common CRP gene polymorphisms (e.g., rs1205 and rs3091244) influence baseline CRP levels and reactivity, contributing to interindividual variability in systemic inflammation, whereas variants in NR3C1 and BcLI, which encode the glucocorticoid receptor, affect HPA axis feedback and cortisol sensitivity, further modulating IL-6 and CRP expression in response to chronic stress and are also associated with increased glucocorticoid sensitivity, a greater insulin response, and, in some cases, greater abdominal obesity.