FOXO1 and type 2 diabetes mellitus: Both substances were proven to be ligands for PI3K in in silico molecular docking studies and in vivo, where they enhanced gene expression for PI3K and FOXO1 in the liver, as well as PI3K, p-AKT, FOXO1, and adenosine monophosphate-activated protein kinase (AMPK) in the pancreas of type 2 diabetic rats.