BDNF and early-onset autosomal dominant Alzheimer disease: Resistance training has been associated with decreased risk of chronic low-grade inflammation [11] and sustained resistance training appears to lower pro-inflammatory cytokine levels both at rest and in response to exercise [12]; increase the secretion of brain-derived neurotrophic factors (BDNF) [13]; and, in animal models of Alzheimer’s disease, has demonstrated the ability to promote Aβ clearance [14] and reduce both the volume and number of Aβ plaques and intracellular neurofibrillary tangles in the brain [6].