The 2022 Best-Practice Guidelines (BPGs) for SSI in high-risk paediatric spine surgery reported a syndromic and neuromuscular aetiology of scoliosis, BMI < 15 or >30, preoperative albumin < 3 mg/dL, ASA score IV or higher, diabetes, preoperative steroid use, non-ambulatory status, presence of baclofen pump, presence of ventriculoperitoneal shunt, urinary incontinence, positive urine cultures, thirteen levels of fusion or greater, and fusion to pelvis as risk factors for developing an SSI [7]. The gene discussed is ALB; the disease is diabetes mellitus.