CD4 and Miyoshi myopathy: However, the frequency of the CD57CD28- subset, which is considered a marker of early senescence alongside highly differentiated phenotype [33], was significantly higher in the CD4+ CM T cell subset in the ME-MM group compared to the ME-SA group, with a non-significant trend (p = 0.0899) towards higher frequency also in the CD4+ EM T cells in the ME-MM group (Fig. 2a).