Moreover, a similar pattern was also seen in CD8+ T cells, with the frequency of CD57-CD28- cells in the CD8+ EM and CD8+ TEMRA T cell subsets being significantly elevated in ME-MM compared to ME-SA (p = 0.012 in CD8+ EM, p = 0.0598 in CD8+ TEMRA) (Fig. 2b). This evidence concerns the gene CD28 and Miyoshi myopathy.