Firstly, we compared the frequencies of T cells (identified as CD3+) and T cell subsets (CD4+ T cells, CD8+ T cells, CD4CD8 Double Negative (DN) T cells, CD4+CD8+ Double Positive (DP) T cells, CD3+CD56+ NKT-like cells), as well as NK cells (identified as CD3-CD56+) and CD8+CD56+NK cells (“NK8 cells”) in ex vivo PBMCs from people with ME-MM or ME-SA, and found there were no differences between the two clinical groups (Supplementary Figure S2a-2 h). Here, CD4 is linked to Miyoshi myopathy.