We also found that MAIT cell activation by PMA and ionomycin changed the proportion of subsets compared to the non-stimulated condition, with an increase of DN MAITs (from 33.1% to 43.9% in ME-MM and from 23.9% to 35.1% in ME-SA) and a reduction of CD8+ MAITs (from 63.8% to 46.5% in ME-MM and from 74.3% to 58.9% in ME-SA) in both groups (Supplementary Figure S8). The gene discussed is CD8A; the disease is Miyoshi myopathy.