In esophageal squamous cell carcinoma, the upregulation of the lncRNA cancer susceptibility candidate 8 (CASC8) through ALKBH5-mediated m6A demodifications stabilizes the CASC8 transcript, thereby negatively modulating the caspase-3 apoptotic pathway [252]. The gene discussed is CASC8; the disease is esophageal squamous cell carcinoma.