Considering that RNA modifications significantly regulate the expression of HK2, it is reasonable to hypothesize that m6A modifiers, including METTL3, METTL14, KIAA1429, YTHDC1, YTHDF1-3, IGF2BP2, FTO and ALKBH5, may mediate PD-L1 expression and tumor immune escape through the regulation of HK2 mRNA modifications. The gene discussed is IGF2BP2; the disease is neoplasm.