NLRP3 mRNA can be stabilized by METTL3, METTL14, WTAP, IGF2BP1 and IGF2BP2, thereby enhancing the NLRP3/caspase-1/GSDMD-related classical pyroptosis signaling pathway in contexts such as kidney injury in diabetic nephropathy, arsenic-induced hepatic insulin resistance, human umbilical cord mesenchymal stem cells and gefitinib-acquired resistance in lung cancer [229–232]. Here, NLRP3 is linked to Insulin resistance.