METTL3 and neoplasm: METTL3-, YTHDF1- and IGF2BP3-dependent m6A modification on the 5’UTR of PDK4 mRNA positively regulates its translation elongation and mRNA stability, whereas WTAP-mediated m6A modification on PDK4 mRNA downregulates PDK4 expression levels and facilitates tumor cell progression, indicating opposing effects of m6A modifications on PDK mRNA [27, 193].