In macrophages, GLUT1 and glycolysis can be upregulated through the tumor-derived exosome (TDE)/TLR2/NF-κB/HIF-1α signaling pathway, leading to increased cellular lactate, which subsequently feeds back on NF-κB to further enhances PD-L1 expression [303]. The gene discussed is SLC2A1; the disease is neoplasm.