HK2 can be directly mediated by the m6A modifiers METTL3, YTHDF1, IGF2BP2, FTO and ALKBH5 in colorectal cancer and cervical cancer, leading to increased glycolysis, upregulated aerobic respiration in mitochondria and tumor progression [170, 176–179]. Here, IGF2BP2 is linked to cervical carcinoma.