METTL3 and glioblastoma: In glioblastoma and hepatocarcinoma, the expression level of SLC7A11 can be upregulated in an m6A-dependent manner with the assistance of METTL3 and IGF2BP1 via the inhibition of SLC7A11 mRNA degradation and increased SLC7A11 mRNA splicing and maturation [212, 213].