GLS and neoplasm: Furthermore, NSUN2-mediated m5C modifications of the lncRNA NR-033928 interact with IGF2BP3 to promote glutaminase (GLS) mRNA stability, leading to increased production of glutamate and α-KG, along with succinyl-coenzyme A, which is catalyzed by α-ketoglutarate dehydrogenase (OGDH) demethylated by ALKBH5, collectively accelerating the TCA cycle rate and tumor development [15, 197].