HK2 can be directly mediated by the m6A modifiers METTL3, YTHDF1, IGF2BP2, FTO and ALKBH5 in colorectal cancer and cervical cancer, leading to increased glycolysis, upregulated aerobic respiration in mitochondria and tumor progression [170, 176–179]. The gene discussed is ALKBH5; the disease is neoplasm.