METTL16 and glioma: Studies have demonstrated that c-MYC can upregulate FDX1 via YTHDF1 with increased sensitivity to cuproptosis in glioma cells and that copper stress promotes METTL16 lactylation, leading to elevated METTL16 expression, which positively mediates cuproptosis through the m6A modification of FDX1 mRNA.