Nevertheless, it seems that NLRP3/IL-18 are not always immunosuppressive factors, particularly in the context of colorectal cancer metastasis in the liver, where the NLRP3 inflammasome generated in Kuppfer cells induces immunosurveillance via NK cells but not CD8+ T cells, and IL-18 positively mediates NK cell maturation and tumoricidal activity independent of IFN-γ and suppresses metastasis [318]. This evidence concerns the gene IL18 and colorectal cancer.