LPCAT3 and neoplasm: Notably, when tumor-bearing mice were treated with a liver X receptor (LXR) agonist, expression of lysophosphatidylcholine acyltransferase 3 (LPCAT3) was induced, which counteracts lipid-induced ER stress by synthesizing phosphatidylcholine enriched with unsaturated fatty acids; this in turn decreased XBP1s levels in TAMs, resulting in improved survival of the tumor-bearing mice [174].