In bone marrow-derived macrophages (BMDMs) exposed to conditioned media from colorectal cancer cells, the presence of XBP1s directly stimulated the expression of VEGFA, IL4, IL6, and ligands associated with “don't eat me” signals, such as signal regulatory protein α (SIRPα) and thrombospondin 1 (THBS1) [172]. This evidence concerns the gene THBS1 and colorectal cancer.