E2F3 and neoplasm: To investigate whether E2F3 overexpression could counteract the tumor-suppressive effects of circ_0001741 silencing, we performed rescue experiments using five experimental groups: Blank control; si-circ_0001741; miR-194-5p mimic; si-circ_0001741 + E2F3 overexpression; miR-194-5p mimic + E2F3 overexpression.