STAT3 and type 1 diabetes mellitus: Conversely, in the comparison T1DM-/HC EV proteins were able to predict a significant activation of the same genes: HNF1A (z-score = 2.03, p-value = 1.48 × 10−16) and STAT3 (z-score = 2.10, p-value = 6.16 × 10−9), as displayed in Fig. 4B. The simultaneous modulation of HNF1A and STAT3 as regulatory factors supported the suppression of fatty acid metabolism in T1DM young people with IR through EVs, potentially leading to liver damage, since HNF1A plays an important role in maintaining liver lipid homeostasis [56].