Conversely, in the comparison T1DM-/HC STAT3 was predicted as significant activated upstream (z-score = 2.10, p-value = 6.16 × 10−9), as reported in Fig. 3B. Accordingly, our proteomics data showed that this modulation at origin cells level was exploited by EVs that were well packaged to deliver information related to “fatty acid metabolism”, whose function was slightly reduced in T1DM + EVs (z-score = −1.54, p-value = 9.27 × 10−9, Fig. 3C), but it was predicted significantly activated in T1DM- EVs (z-score = 2.12, p-value = 2.10 × 10−9, Fig. 3D) compared to HC ones. This evidence concerns the gene STAT3 and type 1 diabetes mellitus.