STAT3 and type 1 diabetes mellitus: In particular, Fig. 4A showed the interactive network of HNF1A (z-score = −2.16, p-value = 2.83 × 10−10) and STAT3 (z-score = −2.66, p-value = 7.64 × 10−10) as significant inhibited upstream regulators by T1DM + EVs compared to HC ones.