FABP5 and obesity due to melanocortin 4 receptor deficiency: As a matter of fact, on the one hand T1DM + EVs are able to vehiculate pathological messages related to liver lesion (Fig. 2) and fatty acid metabolism (Fig. 3) unravelling not only specific EV proteins, such as FABP5, involved in obesity and obesity-induced IR [66], but also the functional and active role the EVs have in diabetes-related complications associated to IR, as demonstrated by higher levels of unsaturated and saturated long-chain ACs (C18:1, C18:2 and C14) found in DBS of T1DM + children patients respect to T1DM- ones.