As a matter of fact, as shown in the network of Fig. 3A the most significant inhibited upstream in T1DM + EVs respect to HC EVs was signal transducer and activator of transcription 3 (STAT3) with a z-score of −2.66 (p-value = 7.64 × 10−10). This evidence concerns the gene STAT3 and type 1 diabetes mellitus.