Mechanistic network of Fig. 2A showed that the strong activation of “liver lesion” was exploited by 67 T1DM + EV proteins, between them fatty acid-binding protein 5 (FABP5) was quantified as exclusive protein in T1DM + EVs (fold change = 100), and not in T1DM- EVs, as highlighted by red circle in the network of Fig. 2A. FABPs are a family of small cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands [53] and, simultaneously, polymorphisms in FABP5 gene are associated with T2DM. The gene discussed is FABP5; the disease is type 1 diabetes mellitus.