Our study identified several key genes implicated in BL tumorigenesis, including MYC, DDX3X, ID3, and TP53. EBV-negative tumors displayed a higher frequency of chromosomal amplifications, particularly at 7p12.2, 6q25.3 and 7q22.1 and two novel variants of KMT2D were identified in adult patients of the EBV-negative group. Here, TP53 is linked to Burkitt lymphoma.