We excluded genes with mutation frequencies below 5% to assess gene mutual exclusivity and co-occurrence in BL patients (Fig. 1B). We found mutual exclusivity between KMT2D and MYC mutations, and concurrent mutations between FOXO1 and DDX3X, FBXO11 and DDX3X, PTEN and GNA13, among others (Fig. 1B). The gene discussed is DDX3X; the disease is Burkitt lymphoma.