EBV-positive BL demonstrates a distinct transcriptional profile compared to EBV-negative cases, marked by pronounced upregulation of RNF19B, MBNL1-AS1, IFI44L, DENND4A, PTPRO, and significant downregulation of CRHBP, GRIK3, CTCFL, ESPNL, and AC011747 (Fig. 3A-B). Here, DENND4A is linked to Burkitt lymphoma.