The receptor activator of the nuclear factor-κB (NF-κB) ligand (RANKL)/receptor activator of the NF-KB (RANK)/osteoprotegerin (OPG) pathway has been identified as the primary regulator of osteoporosis, and genetic variations in RANK have been linked to the pathogenesis of its osteoporosis [10]. Here, TNFRSF11B is linked to osteoporosis.